Strategies for Measuring Viable Biomass

Genetic Engineering and Biotechnology News
Apr 1 2009 (Vol. 29, No. 7)
John Carvell

Novel Technique Aims to Extend Application of RF Impedance to Single-Use Bioreactors

Of the available on-line biomass assays, the radio-frequency impedance method (often referred to as capacitance) is generally regarded as the most robust and reliable method to monitor viable biomass during fermentation and cell culture.

The first paper to show that capacitance could be used to estimate microbial biomass dates back over 20 years, and today the technology is routinely used for monitoring and controlling mammalian cell culture processes and high-density yeast and bacterial fermentations in research, process development, and manufacturing applications.

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