Protein Purification Process for BioEnergy Recognised on Front Cover of Microfluidics Journal

The paper is titled Rapid, continuous purification of proteins in a microfluidic device using genetically-engineered partition tags. Authored by Sandia/California’s Robert Meagher, Yooli Light, and Anup Singh, it describes a rapid, automated microscale process for isolating specific proteins from sub-microlitre volumes of E. coli cell lysate.

Sandia is a National Nuclear Security Administration laboratory.

“This novel approach addresses the need for high-throughput purification of minute amounts of native and recombinant proteins, which is currently necessary in drug discovery, enzyme engineering, and other life sciences”, says Sandia’s Robert Meagher, the lead author. High-throughput screening requires availability of large numbers of purified proteins, but current purification techniques are too slow, expensive, and hard to automate.

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